The purpose of this paper is to explore the interconnected processes of care depicted in the movie 《House of Cards》 by following the narratives of its characters and to reflect on the significance of holistic care. This movie explores the doctor’s and the patient’s family’s approaches to illness and care from both biomedical and existential perspectives, with a focus on the patient. The doctor’s narrative depicts disease approach and cure from a biomedical perspective, while the patient’s family’s narrative depicts illness and care from an existential perspective. The perspective on disease varies depending on the presence or absence of medical knowledge and recognition of human individuality. Medical professionals view the disease as something that must be eliminated, but patients and their families understand the disease as part of the context of their lives. The movie leads this point into a conflict of interest about the disease, and solves the problem of the patient’s pain beyond medical diagnosis through human-centered holistic care. This is described as a process in which the doctor and the patient’s family, starting from different perspectives on the disease, acknowledge the patient’s individuality, understand the patient’s narrative, and experience reflection and joint healing in an interconnected relationship. The interconnected care suggested by this moive provides an opportunity to rethink the role and position of care in current medical practice.